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Phabioc

PermeaPad GIT Barrier

PermeaPad GIT Barrier

  • 50 pieces per unit
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The biomimetic barrier for reliable in vitro permeability tests

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Our innovative permeability assays offer a breakthrough in both the conventional vertical diffusion cell and the 96-well microtiter plate.*With our biomimetic GIT barrier (PermeaPad® GIT), we simulate the cell barriers of the gastrointestinal tract and the oral and nasal mucosa. This ready-to-use barrier enables simple, rapid, and reproducible measurements without pretreatment or animal testing. Their robustness allows for precise adjustment of environmental parameters to simulate in vivo situations. They are also compatible with liquid handling platforms.

*For research purposes only. Not for use in diagnostic procedures.

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Possible applications in drug development

PermeaPad® GIT Barrier simulates various biological barriers – from the oral and nasal mucosa to the stomach and small intestine to the lungs. It is ideal for permeability studies in preclinical research and allows the analysis of passive drug transport under realistic conditions.

Example applications:

🧫 Oral mucosa with saliva

🧫 Nasal mucosa

🧫 Gastrointestinal model

🧫 Lung model (with mucus)

🧫 Skin (in combination with Skin Barrier)

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Why GIT Barrier?

  • 🧬 Biomimetic model for oral, nasal, pulmonary & intestinal barriers
  • 🧪 Compatible with standard setups such as Franz cells & side-by-side cells
  • ⏱️ Fast & reproducible measurements without complex handling
  • 🧷 Mechanically stable & storable – ideal for long-term projects
  • ⚗️ Use in wide pH ranges – flexibly adaptable
  • 📏 Available in various sizes – can also be cut to size

When conventional models reach their limits...

  • Challenges of classical permeability assays

    ❌ Complex production of biological barriers

    ❌ Low reproducibility

    ❌ Limited stability & storage capacity

    ❌ Limited pH range

  • The solution with PermeaPad® GIT Barrier

    ✅ Easy handling with high stability

    ✅ Durable & long-lasting

    ✅ Biological relevance through biomimetic material

    ✅ Ideal for oral, nasal, gastrointestinal and pulmonary models
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Frequently Asked Questions

For what purpose was the PermeaPad® GIT Barrier developed?

For realistic simulation of biological membranes for in vitro diffusion tests.

Is the barrier compatible with Franz cells?

Yes, it can be used in Franz cells, side-by-side cells, and other common setups.

How is the barrier stored?

The PermeaPad® GIT Barrier is mechanically stable and can be easily stored at room temperature (~25°C). Protect from direct sunlight.

In which pH ranges can I use them?

The barrier can be used in a wide pH range – ideal for different substance classes.

Are custom cuts possible?

Yes, we offer cuts up to 230 × 230 mm on request.

Designed for demanding research

The PermeaPad® GIT Barrier is specifically designed for use in preclinical research. It was developed in close collaboration with leading laboratories and is already used in numerous publications. It is ideal for pharmaceutical companies, CROs, and university research institutions.

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